陈家良，2006-2010年本科就读于山东师范大学，2010-2016年硕博连读于南开大学,2017-2022年于南开大学从事博士后研究工作。2022年加入枣庄学院，主讲《分析化学A》、《无机化学实验A2》等课程。作为项目负责人主持国家博士后创新人才支持计划项目（“博新计划”BX201700124）、国家自然科学基金青年项目（22004072）、山东省高校青年创新团队支持计划项目（2022KJ279），作为主要成员参与国家自然科学基金委员会与以色列科学基金会合作研究项目1项。担任ACS期刊Anal. Chem.审稿人，在国际权威期刊Angew. Chem. Int. Ed., J. Am. Chem. Soc., J. Phys. Chem. Lett., Chem. Commun., Nano. Lett., Chem. Eur. J., ChemBioChem, Phys. Chem. Chem. Phys., J. Biomol. NMR等发表论文20余篇，参与编写Elsevier专著1部（一章节）。

 

主持基金项目：

1、2018 - 2019：博士后创新人才支持计划（BX201700124）（20万，已结题）

2、2021 - 2023：国家自然科学基金青年项目（22004072）：细胞内定点标记蛋白质并应用于高分辨生物磁共振研究（24万，在研）

3、2023 - 2025：山东省高校“青创团队计划”项目（2022KJ279）：重大疾病代谢物的多模态原位定量分析（30万，在研，带头人）

 

发表论文：

[1] Ya-Ting Chen, Bin Li, Jia-Liang Chen, Xun-Cheng Su. Stereospecific recognition of a chiral centre over multiple flexible covalent bonds by ¹⁹F-NMR. Analyst 2023, 148, 233-238.

[2] Chao-Yu Cui,† Bin Li,† Dan Cheng, Xia-Yan Li, Jia-Liang Chen, Ya-Ting Chen, and Xun-Cheng Su*. Simultaneous Quantification of Biothiols and Deciphering Diverse GSH Stability in Different Live Cells by ¹⁹F‑Tag. Anal. Chem. 2022, 94 (2), 901-908.

[3] Jia-Liang Chen, Bin Li, Bo Ma, Xun-Cheng Su. Distinct stereospecific effect of chiral tether between a tag and protein on the rigidity of paramagnetic tag. J. Biomol. NMR, 2022, 76, 107-119.

[4] Bo Ma†, Jia-Liang Chen†, Chao-Yu Cui†, Feng Yang, Yan-Jun Gong, and Xun-Cheng Su*. Rigid, Highly Reactive and Stable DOTA-like Tags Containing a Thiol-Specific Phenylsulfonyl Pyridine Moiety for Protein Modification and NMR Analysis. Chem. Eur. J. 2021, 27(65):16145-16152. (共同一作)

[5] Jia-Liang Chen, Ben-Guang Chen, Bin Li, Feng Yang and Xun-Cheng Su*. Assessing multiple conformations of lanthanide inding tags for proteins using a sensitive ¹⁹F-reporter. Chem. Commun. 2021, 57, 4291-4294.

[6] Ya-Ting Chen†, Bin Li†, Xia-Yan Li, Jia-Liang Chen, Chao-Yu Cui, Kaifeng Hu*, Xun-Cheng Su*. Simultaneous identification and quantification of amino acids in biofluids by reactive ¹⁹F-tags. Chem. Commun. 2021, 57 (97), 13154-13157.

[7] Guilan Fan, Wence Xu, Jinhan Li, Jia-Liang Chen, Meng Yu, Youxuan Ni, Shengli Zhu, Xun-Cheng Su, Fangyi Cheng. Nanoporous NiSb to Enhance Nitrogen Electroreduction via Tailoring Competitive Adsorption Sites, Adv. Materials, 2021, 33(42): 2101126.

[8] Wence Xu†, Guilan Fan†, Jialiang Chen, Jinhan Li, Le Zhang, Shengli Zhu, Xuncheng Su, Fangyi Cheng* and Jun Chen. Nanoporous Palladium Hydride for Electrocatalytic N₂ Reduction under Ambient Conditions. Angew. Chem. Int. Ed. 2020, 59, 3511-3516.

[9] Qiang Li, Jialiang Chen, Marko Trajkovski, Yifei Zhou, Chaochao Fan, Kuan Lu, Pingping Tang, Xuncheng Su, Janez Plavec,* Zhen Xi and Chuanzheng Zhou*. 4′-Fluorinated RNA: Synthesis, Structure, and Applications as an Ultra-Sensitive ¹⁹F NMR Probe of RNA Structure and Function. J. Am. Chem. Soc. 2020, 142(10): 4739-4748.

[10] Ran Hao, Wenming Sun, Qian Liu, Xiaolu Liu, Jialiang Chen, Xianwei Lv, Wei Li, Yu-ping Liu, Zhurui Shen. Efficient Electrochemical Nitrogen Fixation over Isolated Pt Sites, Small, 2020, 16(22): 2000015.

[11] Jia-Liang Chen†, Bin Li†, Xia-Yan Li, and Xun-Cheng Su*. Dynamic Exchange of the Metal Chelating Moiety: A Key Factor in Determining the Rigidity of Protein−Tag Conjugates in Paramagnetic NMR. J. Phys. Chem. Lett. 2020, 11, 9493−9500.

[12] Xun-Cheng Su*, Jia-Liang Chen. Site-Specific Tagging of Proteins with Paramagnetic Ions for Determination of Protein Structures in Solution and in Cells. Acc. Chem. Res. 2019, 52, 1675−1686.

[13] Jia-Liang Chen, Xiao Wang, Yu-Hao Xiao and Xun-Cheng Su*. Resonance assignments of lowly populated and unstable enzyme intermediate complex under real-time conditions. ChemBioChem, 2019, 20, 2738-2742.

[14] Mingming Li†, Yashan Ning†, Jialiang Chen, Xingchen Duan, Na Song, Dan Ding*, Xuncheng Su*, and Zhilin Yu*. Proline Isomerization-Regulated Tumor MicroenvironmentAdaptable Self-Assembly of Peptides for Enhanced Therapeutic Efficacy. Nano Lett. 2019, 19, 7965−7976.

[15] Xiao Wang, Jia-Liang Chen, Gottfried Otting, Xun-Cheng Su. Conversion of an amide to a highenergy thioester by Staphylococcus aureus sortase A is powered by variable binding affinity for calcium. Sci. Rep. 2018, 8, 16371.

[16] Jia‑Liang Chen†, Yu Zhao†, Yan‑Jun Gong, Bin‑Bin Pan, Xiao Wang, Xun‑Cheng Su*. Stable and rigid DTPA-like paramagnetic tags suitable for in vitro and in situ protein NMR analysis. J. Biomol. NMR 2018, 70, 77-92.

[17] Yin Yang†, Feng Yang†, Yan-Jun Gong, Jia-Liang Chen, Daniella Goldfarb,* and XunCheng Su*. A Reactive, Rigid GdIII Labeling Tag for In-Cell EPR Distance Measurements in Proteins. Angew. Chem. Int. Ed. 2017, 56, 2914-2918.

[18] Fei-He Ma, Xiao Wang, Jia-Liang Chen, Xin Wen, Han Sun, Xun-Cheng Su. Deciphering the Multisite Interactions of a Protein and Its Ligand at Atomic Resolution by Using Sensitive Paramagnetic Effects, Chem. Eur. J. 2017, 23(4): 926-934.

[19] Jia-Liang Chen, Xiao Wang, Feng Yang, Chan Cao, Gottfried Otting, and Xun-Cheng Su*. 3D Structure Determination of an Unstable Transient Enzyme ntermediate by Paramagnetic NMR Spectroscopy. Angew. Chem. Int. Ed. 2016, 55, 13744-13748.

[20] Jia-Liang Chen, Yin Yang, Lin-Lin Zhang, Haobo Liang, Thomas Huber, Xun-Cheng Su* and Gottfried Otting*. Analysis of the solution conformations of T4 lysozyme by paramagnetic NMR spectroscopy. Phys. Chem. Chem. Phys. 2016, 18, 5850-5859.

[21] Fei-He Ma†, Jia-Liang Chen†, Qing-Feng Li†, Hui-Hui Zuo, Feng Huang, and Xun-Cheng Su*. Kinetic Assay of the Michael Addition-Like Thiol–Ene Reaction and Insight into Protein Bioconjugation. Chem. Asian J. 2014, 9, 1808 – 1816. (共同一作)

[22] Chan Cao, Jia-Liang Chen, Yin Yang, Feng Huang, Gottfried Otting, Xun-Cheng Su*. Selective ¹⁵N-labeling of the side-chain amide groups of asparagine and glutamine for applications in paramagnetic NMR spectroscopy. J. Biomol. NMR. 2014, 59, 251-261.